Larry has enough money to access the best doctors, experimental treatments, and pretty much any longevity research available, so I wouldn't be surprised if he makes it well into his 90s or even past 100. But 120 or 150 seems pretty unrealistic. Genetics, biology, and plain old luck still matter, and nobody has figured out how to stop aging. AI might eventually accelerate medical breakthroughs, but there's a big difference between extending a healthy lifespan and somehow making people live forever. Money buys options, not guarantees.
What I find more interesting is whether Larry will ever voluntarily step away from Oracle. He's already built an empire, accumulated more wealth than anyone could reasonably spend, and still seems determined to remain involved in everything. I wouldn't be surprised if he's making major decisions right up until his final days. The bigger question is what happens to Oracle when he's no longer around. So much of the company's identity and direction has been tied to one person for decades. That's a much more interesting question than whether he makes it to 100 or 120.