I hate to say it, because I have quite a bit of time in total including pre-acquisition/merger time, but I think 2019 might be the year I sharpen up the resume and start looking elsewhere. This is by no means the first layoff rodeo I've rode in during my time.
The reason I hate to say it is because there's a lot of great people who actually care about delivering quality product, who believe that HIT is the future and that it can do a lot of good in the world - and those people are one of the reasons I've stuck it out this long. When you're in a position that there's really no way out of - no way up that's appealing at any rate - your relatively stable "safe" job seems more and more like a trap. The workloads are increasing at a crazy rate, nothing makes sense anymore, there's a reek of desperation in the air, and lots of names are disappearing from the email address book it may certainly be time to start looking elsewhere.
Best of luck to those who escape and find greener pastures.